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KMID : 1197720140070010019
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대한파킨슨병 및 이상운동질환 학회지
2014 Volume.7 No. 1 p.19 ~ p.21
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Stiff-Person Syndrome: Case Series
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Jung Yu-Jin
Jeong Han-Gil
Kim Ryul
Kim Han-Joon
Jeon Beom-Seok
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Abstract
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Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of our patients respond favorably to gamma amino butyric acid-enhancing drugs and immunotherapies.
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KEYWORD
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Stiff-person syndrome, Glutamic acid decarboxylase antibody, Autoimmune disease
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